library(coda)
library(bayesplot) 
library(ggplot2)
library(ggsci)
library(khroma)
library(tidyverse)
library(reshape2)
library(here)
knitr::opts_chunk$set(echo = TRUE, dpi = 300 )

Set up MCSim file

# this markdown file must be saved in top level directory for the following to work; the mcsim code depends on getwd results.
mdir <- "MCSim"
source(here::here(mdir,"setup_MCSim.R"))
# Make mod.exe (used to create mcsim executable from model file)
makemod() 
The mod.exe had been created.

Set filenames and load data

Set up dataset

id_lut <- multicheck$df_check %>% select(Level) %>% unique ()  %>%
  mutate(dataset = c( 
    rep("Decatur M Train", 9),
    rep("Decatur F Train", 9),
    rep("Decatur M Test", 9),
    rep("Decatur F Test", 10),
    'Paulsboro-Train','Horsham-Train',
    'Warminster-Test','Warrington-Train'), 
    Sex = c( 
    rep("M", 9),
    rep("F", 9),
    rep("M", 9),
    rep("F", 10),
    'Mixed', 'Mixed',  'Mixed', 'Mixed'),
    City = c( 
    rep("Decatur", 18),
    rep("Decatur", 19),
    'Paulsboro','Horsham','Warminster','Warrington'), 
    Train_Test = c( 
    rep("Train", 9),
    rep("Train", 9),
    rep("Test", 9),
    rep("Test", 10),
    'Train', 'Train', 'Test', 'Test'),
    datatype = c(
      rep("Individual",9+9+9+10),
      rep("Summary",4)),
    Simulation = row_number(),
    variable = paste0(dataset, " ",Simulation))

id_lut$dataset <- factor(id_lut$dataset,levels=
                           c("Decatur M Train","Decatur F Train","Arnsberg M Train",
                             "Arnsberg F Train","Decatur M Test","Decatur F Test","Arnsberg M Test",
                             "Arnsberg F Test","Minnesota Train","Minnesota Test",
                             'Lubeck-Bartell-Train', 'Lubeck-Bartell-Test',
                             'Little Hocking-Bartell-Train', 'Little Hocking-Bartell-Test',
                             'Little Hocking-Emmett-Test','Paulsboro-Train','Horsham-Train',
                             'Warminster-Test','Warrington-Train'))
id_lut$City <- factor(id_lut$City,levels = 
                        c("Decatur","Arnsberg","Minnesota",'Lubeck-Bartell',
                          'Little Hocking-Bartell','Little Hocking-Emmett',
                          'Paulsboro','Horsham','Warminster','Warrington'))
 

indiv_lut <- id_lut %>% 
  filter(City %in% c("Decatur")) %>%
  mutate(  dataset = as.factor(dataset))

nv <- data.frame(dataset =unique(indiv_lut$dataset), 
           variable= rep("Pop GM", 4),
           type= rep("Pop GM", 4), stringsAsFactors = FALSE)

Scatter plot of predictions (median of multicheck samples) versus data.

This is a Figure 2 panel. Needed to use “scale=1.1” in ggsave to match PFOA.

nrow(multicheck$df_check)
[1] 39000
nrow(id_lut)
[1] 41
multicheck$df_check %>% left_join(id_lut) %>% nrow()
Joining, by = c("Level", "Simulation")
[1] 39000
names(multicheck$df_check)
[1] "Level"      "Simulation" "Output_Var" "Time"       "Data"      
[6] "Prediction"
Level

Simulation

Output_Var

Time

Data

Prediction
multicheck2 <- multicheck$df_check %>% 
  left_join(id_lut, by = c("Level", "Simulation"))%>% 
  group_by_at ( vars(-Prediction)) %>% 
  summarise(Prediction = median(Prediction)) %>%
  ungroup() %>%
  group_by(City) %>% 
  mutate(Train_Test = factor(Train_Test, levels = c("Train", "Test")),
         `City (datatype)` = factor (paste0(City, "\n(", datatype, ")\n") ),
         label = case_when(Train_Test=="Train" ~ "G: PFHxS Train",
                           Train_Test=="Test"  ~ "H: PFHxS Test",
                           TRUE ~ ""))
Warning in mutate_impl(.data, dots, caller_env()): Unequal factor levels:
coercing to character
Warning in mutate_impl(.data, dots, caller_env()): binding character and factor
vector, coercing into character vector

Warning in mutate_impl(.data, dots, caller_env()): binding character and factor
vector, coercing into character vector

Warning in mutate_impl(.data, dots, caller_env()): binding character and factor
vector, coercing into character vector

Warning in mutate_impl(.data, dots, caller_env()): binding character and factor
vector, coercing into character vector

Warning in mutate_impl(.data, dots, caller_env()): binding character and factor
vector, coercing into character vector
#define color for testing boxplots
bp_cols <- c (as.character (khroma::colour("muted")(9)) , "#191919")   
bp_cols <-bp_cols[c(1,7,10:8)]# plot_scheme_colourblind(bp_cols) 

### Create aesthetics lookup
aes_lut <- multicheck2 %>% ungroup() %>% 
  group_by(City, datatype,  `City (datatype)` ) %>% summarise () %>% ungroup() %>%
  mutate( cols = bp_cols, city_fills =   bp_cols , 
          # for individual level on point plot (multicheck2), darken outlines for visibility, use standard colors otherwise
         city_outlines =  if_else(datatype == "Individual"  ,  colorspace::darken(city_fills, 0.3), city_fills) ,  
         shapes = case_when(datatype == "Individual"  & `City` %in% c('Decatur', 'Arnsberg', 'Minnesota')   ~  23,
                            datatype == "Summary" &`City` %in% c("Horsham", "Warminster",  "Warrington") ~ 2,
                            datatype == "Summary" & `City` == "Paulsboro" ~ 1,
                            TRUE ~ 18                                ), 
         size = if_else(datatype =="Individual", 1.75, 2.5 ) )  



source( paste0(gsub(basename(here()), 'shared_functions', here()), '/plot_scatter_mcheck.r'))

p2 <- plot_scatter_mcheck(dframe = multicheck2,  pfas_nom = pfas_name, aes_lut_fn = aes_lut )
print(p2) 

ggsave(here ("output-plots", paste0( sa,"multicheckplot_", pfas_name,
               ".pdf")),p2,dpi=600, scale=1.1)
Saving 8.8 x 3.85 in image

Parse multicheck

df_check <- multicheck$df_check
df_check <- subset(df_check,Data > 0) 

n1 <- nrow(df_check)
id_chks <- df_check %>% select(Level) %>% unique() %>% bind_cols(id_lut)  %>%
  mutate(dataset = as.factor(dataset), Sex = as.factor(Sex), City = as.factor(City), 
         Train_Test = as.factor(Train_Test))

df_check <- df_check %>% left_join(id_chks)%>%
  mutate(Dataset = paste(as.character(dataset), Simulation),
         Sex = ordered(Sex, levels = c("M", "F", "Mixed"), 
                       labels = c("Male", "Female", "Mixed (all sexes)")))
Joining, by = c("Level", "Simulation")
n2 <- nrow(df_check)
if(n1 != n2)print("duplicates created in id-lut join")
df_check$Time.desc <- as.character(paste0("T=",df_check$Time))
df_check$Time.desc[df_check$Time.desc == "T=1e-06"] <- "SteadyState"
df_check$Dataset.Time <- interaction(df_check$Dataset,
                                     df_check$Time.desc,lex.order=TRUE)
df_check$Dataset.Time <- factor(df_check$Dataset.Time,
                                levels=levels(df_check$Dataset.Time))
calibdata <- df_check[,names(df_check) != "Prediction"]
calibdata <- calibdata[!duplicated(calibdata),]
print(calibdata)
        Level Simulation Output_Var  Time   Data     Level1          dataset
1   1_1_1_1_1          1     Cserum 0.000 15.400  1_1_1_1_1  Decatur M Train
2   1_1_1_1_1          1     Cserum 5.802 16.600  1_1_1_1_1  Decatur M Train
3   1_1_1_1_2          2     Cserum 0.000  4.900  1_1_1_1_2  Decatur M Train
4   1_1_1_1_2          2     Cserum 5.802  6.100  1_1_1_1_2  Decatur M Train
5   1_1_1_1_3          3     Cserum 0.000 11.300  1_1_1_1_3  Decatur M Train
6   1_1_1_1_3          3     Cserum 5.802  7.800  1_1_1_1_3  Decatur M Train
7   1_1_1_1_4          4     Cserum 0.000 12.800  1_1_1_1_4  Decatur M Train
8   1_1_1_1_4          4     Cserum 5.802  5.600  1_1_1_1_4  Decatur M Train
9   1_1_1_1_5          5     Cserum 0.000 20.900  1_1_1_1_5  Decatur M Train
10  1_1_1_1_5          5     Cserum 5.802 12.400  1_1_1_1_5  Decatur M Train
11  1_1_1_1_6          6     Cserum 0.000  6.300  1_1_1_1_6  Decatur M Train
12  1_1_1_1_6          6     Cserum 5.802  6.700  1_1_1_1_6  Decatur M Train
13  1_1_1_1_7          7     Cserum 0.000 24.400  1_1_1_1_7  Decatur M Train
14  1_1_1_1_7          7     Cserum 5.802 18.100  1_1_1_1_7  Decatur M Train
15  1_1_1_1_8          8     Cserum 0.000 24.200  1_1_1_1_8  Decatur M Train
16  1_1_1_1_8          8     Cserum 5.802 20.200  1_1_1_1_8  Decatur M Train
17  1_1_1_1_9          9     Cserum 0.000  7.800  1_1_1_1_9  Decatur M Train
18  1_1_1_1_9          9     Cserum 5.802  8.500  1_1_1_1_9  Decatur M Train
19 1_1_1_1_10         10     Cserum 0.000  2.300 1_1_1_1_10  Decatur F Train
20 1_1_1_1_10         10     Cserum 5.802  2.500 1_1_1_1_10  Decatur F Train
21 1_1_1_1_11         11     Cserum 0.000 12.900 1_1_1_1_11  Decatur F Train
22 1_1_1_1_11         11     Cserum 5.802 13.700 1_1_1_1_11  Decatur F Train
23 1_1_1_1_12         12     Cserum 0.000  2.400 1_1_1_1_12  Decatur F Train
24 1_1_1_1_12         12     Cserum 5.802  3.300 1_1_1_1_12  Decatur F Train
25 1_1_1_1_13         13     Cserum 0.000  2.700 1_1_1_1_13  Decatur F Train
26 1_1_1_1_13         13     Cserum 5.802  4.000 1_1_1_1_13  Decatur F Train
27 1_1_1_1_14         14     Cserum 0.000 18.300 1_1_1_1_14  Decatur F Train
28 1_1_1_1_14         14     Cserum 5.802 18.400 1_1_1_1_14  Decatur F Train
29 1_1_1_1_15         15     Cserum 0.000 12.900 1_1_1_1_15  Decatur F Train
30 1_1_1_1_15         15     Cserum 5.802 13.200 1_1_1_1_15  Decatur F Train
31 1_1_1_1_16         16     Cserum 0.000  3.300 1_1_1_1_16  Decatur F Train
32 1_1_1_1_16         16     Cserum 5.802  4.100 1_1_1_1_16  Decatur F Train
33 1_1_1_1_17         17     Cserum 0.000 16.900 1_1_1_1_17  Decatur F Train
34 1_1_1_1_17         17     Cserum 5.802 12.300 1_1_1_1_17  Decatur F Train
35 1_1_1_1_18         18     Cserum 0.000  8.700 1_1_1_1_18  Decatur F Train
36 1_1_1_1_18         18     Cserum 5.802  6.500 1_1_1_1_18  Decatur F Train
37  1_1_1_2_1         19     Cserum 0.000  6.300  1_1_1_2_1   Decatur M Test
38  1_1_1_2_1         19     Cserum 5.802  4.600  1_1_1_2_1   Decatur M Test
39  1_1_1_2_2         20     Cserum 0.000  7.100  1_1_1_2_2   Decatur M Test
40  1_1_1_2_2         20     Cserum 5.802  7.400  1_1_1_2_2   Decatur M Test
41  1_1_1_2_3         21     Cserum 0.000 19.500  1_1_1_2_3   Decatur M Test
42  1_1_1_2_3         21     Cserum 5.802 14.000  1_1_1_2_3   Decatur M Test
43  1_1_1_2_4         22     Cserum 0.000  7.500  1_1_1_2_4   Decatur M Test
44  1_1_1_2_4         22     Cserum 5.802  9.000  1_1_1_2_4   Decatur M Test
45  1_1_1_2_5         23     Cserum 0.000  8.600  1_1_1_2_5   Decatur M Test
46  1_1_1_2_5         23     Cserum 5.802  9.200  1_1_1_2_5   Decatur M Test
47  1_1_1_2_6         24     Cserum 0.000 12.400  1_1_1_2_6   Decatur M Test
48  1_1_1_2_6         24     Cserum 5.802 12.800  1_1_1_2_6   Decatur M Test
49  1_1_1_2_7         25     Cserum 0.000  8.900  1_1_1_2_7   Decatur M Test
50  1_1_1_2_7         25     Cserum 5.802  6.600  1_1_1_2_7   Decatur M Test
51  1_1_1_2_8         26     Cserum 0.000  7.400  1_1_1_2_8   Decatur M Test
52  1_1_1_2_8         26     Cserum 5.802  6.300  1_1_1_2_8   Decatur M Test
53  1_1_1_2_9         27     Cserum 0.000 14.300  1_1_1_2_9   Decatur M Test
54  1_1_1_2_9         27     Cserum 5.802 15.800  1_1_1_2_9   Decatur M Test
55 1_1_1_2_10         28     Cserum 0.000  3.800 1_1_1_2_10   Decatur F Test
56 1_1_1_2_10         28     Cserum 5.802  4.200 1_1_1_2_10   Decatur F Test
57 1_1_1_2_11         29     Cserum 0.000 22.100 1_1_1_2_11   Decatur F Test
58 1_1_1_2_11         29     Cserum 5.802 26.000 1_1_1_2_11   Decatur F Test
59 1_1_1_2_12         30     Cserum 0.000  6.500 1_1_1_2_12   Decatur F Test
60 1_1_1_2_12         30     Cserum 5.802  5.800 1_1_1_2_12   Decatur F Test
61 1_1_1_2_13         31     Cserum 0.000  7.500 1_1_1_2_13   Decatur F Test
62 1_1_1_2_13         31     Cserum 5.802  7.900 1_1_1_2_13   Decatur F Test
63 1_1_1_2_14         32     Cserum 0.000  7.500 1_1_1_2_14   Decatur F Test
64 1_1_1_2_14         32     Cserum 5.802  6.800 1_1_1_2_14   Decatur F Test
65 1_1_1_2_15         33     Cserum 0.000  7.500 1_1_1_2_15   Decatur F Test
66 1_1_1_2_15         33     Cserum 5.802  2.400 1_1_1_2_15   Decatur F Test
67 1_1_1_2_16         34     Cserum 0.000  6.000 1_1_1_2_16   Decatur F Test
68 1_1_1_2_16         34     Cserum 5.802  6.800 1_1_1_2_16   Decatur F Test
69 1_1_1_2_17         35     Cserum 0.000 18.200 1_1_1_2_17   Decatur F Test
70 1_1_1_2_17         35     Cserum 5.802 13.200 1_1_1_2_17   Decatur F Test
71 1_1_1_2_18         36     Cserum 0.000  5.300 1_1_1_2_18   Decatur F Test
72 1_1_1_2_18         36     Cserum 5.802  3.900 1_1_1_2_18   Decatur F Test
73 1_1_1_2_19         37     Cserum 0.000  5.600 1_1_1_2_19   Decatur F Test
74 1_1_1_2_19         37     Cserum 5.802  5.400 1_1_1_2_19   Decatur F Test
75      1_2_1         38 M_Cbgd_Css 2.200  2.593      1_2_1  Paulsboro-Train
76      1_3_1         39 M_Cbgd_Css 2.000 27.340      1_3_1    Horsham-Train
77      1_4_1         40 M_Cbgd_Css 2.000 23.157      1_4_1  Warminster-Test
78    1_4_2_1         41 M_Cbgd_Css 2.000 14.851    1_4_2_1 Warrington-Train
                 Sex       City Train_Test   datatype            variable
1               Male    Decatur      Train Individual   Decatur M Train 1
2               Male    Decatur      Train Individual   Decatur M Train 1
3               Male    Decatur      Train Individual   Decatur M Train 2
4               Male    Decatur      Train Individual   Decatur M Train 2
5               Male    Decatur      Train Individual   Decatur M Train 3
6               Male    Decatur      Train Individual   Decatur M Train 3
7               Male    Decatur      Train Individual   Decatur M Train 4
8               Male    Decatur      Train Individual   Decatur M Train 4
9               Male    Decatur      Train Individual   Decatur M Train 5
10              Male    Decatur      Train Individual   Decatur M Train 5
11              Male    Decatur      Train Individual   Decatur M Train 6
12              Male    Decatur      Train Individual   Decatur M Train 6
13              Male    Decatur      Train Individual   Decatur M Train 7
14              Male    Decatur      Train Individual   Decatur M Train 7
15              Male    Decatur      Train Individual   Decatur M Train 8
16              Male    Decatur      Train Individual   Decatur M Train 8
17              Male    Decatur      Train Individual   Decatur M Train 9
18              Male    Decatur      Train Individual   Decatur M Train 9
19            Female    Decatur      Train Individual  Decatur F Train 10
20            Female    Decatur      Train Individual  Decatur F Train 10
21            Female    Decatur      Train Individual  Decatur F Train 11
22            Female    Decatur      Train Individual  Decatur F Train 11
23            Female    Decatur      Train Individual  Decatur F Train 12
24            Female    Decatur      Train Individual  Decatur F Train 12
25            Female    Decatur      Train Individual  Decatur F Train 13
26            Female    Decatur      Train Individual  Decatur F Train 13
27            Female    Decatur      Train Individual  Decatur F Train 14
28            Female    Decatur      Train Individual  Decatur F Train 14
29            Female    Decatur      Train Individual  Decatur F Train 15
30            Female    Decatur      Train Individual  Decatur F Train 15
31            Female    Decatur      Train Individual  Decatur F Train 16
32            Female    Decatur      Train Individual  Decatur F Train 16
33            Female    Decatur      Train Individual  Decatur F Train 17
34            Female    Decatur      Train Individual  Decatur F Train 17
35            Female    Decatur      Train Individual  Decatur F Train 18
36            Female    Decatur      Train Individual  Decatur F Train 18
37              Male    Decatur       Test Individual   Decatur M Test 19
38              Male    Decatur       Test Individual   Decatur M Test 19
39              Male    Decatur       Test Individual   Decatur M Test 20
40              Male    Decatur       Test Individual   Decatur M Test 20
41              Male    Decatur       Test Individual   Decatur M Test 21
42              Male    Decatur       Test Individual   Decatur M Test 21
43              Male    Decatur       Test Individual   Decatur M Test 22
44              Male    Decatur       Test Individual   Decatur M Test 22
45              Male    Decatur       Test Individual   Decatur M Test 23
46              Male    Decatur       Test Individual   Decatur M Test 23
47              Male    Decatur       Test Individual   Decatur M Test 24
48              Male    Decatur       Test Individual   Decatur M Test 24
49              Male    Decatur       Test Individual   Decatur M Test 25
50              Male    Decatur       Test Individual   Decatur M Test 25
51              Male    Decatur       Test Individual   Decatur M Test 26
52              Male    Decatur       Test Individual   Decatur M Test 26
53              Male    Decatur       Test Individual   Decatur M Test 27
54              Male    Decatur       Test Individual   Decatur M Test 27
55            Female    Decatur       Test Individual   Decatur F Test 28
56            Female    Decatur       Test Individual   Decatur F Test 28
57            Female    Decatur       Test Individual   Decatur F Test 29
58            Female    Decatur       Test Individual   Decatur F Test 29
59            Female    Decatur       Test Individual   Decatur F Test 30
60            Female    Decatur       Test Individual   Decatur F Test 30
61            Female    Decatur       Test Individual   Decatur F Test 31
62            Female    Decatur       Test Individual   Decatur F Test 31
63            Female    Decatur       Test Individual   Decatur F Test 32
64            Female    Decatur       Test Individual   Decatur F Test 32
65            Female    Decatur       Test Individual   Decatur F Test 33
66            Female    Decatur       Test Individual   Decatur F Test 33
67            Female    Decatur       Test Individual   Decatur F Test 34
68            Female    Decatur       Test Individual   Decatur F Test 34
69            Female    Decatur       Test Individual   Decatur F Test 35
70            Female    Decatur       Test Individual   Decatur F Test 35
71            Female    Decatur       Test Individual   Decatur F Test 36
72            Female    Decatur       Test Individual   Decatur F Test 36
73            Female    Decatur       Test Individual   Decatur F Test 37
74            Female    Decatur       Test Individual   Decatur F Test 37
75 Mixed (all sexes)  Paulsboro      Train    Summary  Paulsboro-Train 38
76 Mixed (all sexes)    Horsham      Train    Summary    Horsham-Train 39
77 Mixed (all sexes) Warminster       Test    Summary  Warminster-Test 40
78 Mixed (all sexes) Warrington       Test    Summary Warrington-Train 41
               Dataset Time.desc               Dataset.Time
1    Decatur M Train 1       T=0      Decatur M Train 1.T=0
2    Decatur M Train 1   T=5.802  Decatur M Train 1.T=5.802
3    Decatur M Train 2       T=0      Decatur M Train 2.T=0
4    Decatur M Train 2   T=5.802  Decatur M Train 2.T=5.802
5    Decatur M Train 3       T=0      Decatur M Train 3.T=0
6    Decatur M Train 3   T=5.802  Decatur M Train 3.T=5.802
7    Decatur M Train 4       T=0      Decatur M Train 4.T=0
8    Decatur M Train 4   T=5.802  Decatur M Train 4.T=5.802
9    Decatur M Train 5       T=0      Decatur M Train 5.T=0
10   Decatur M Train 5   T=5.802  Decatur M Train 5.T=5.802
11   Decatur M Train 6       T=0      Decatur M Train 6.T=0
12   Decatur M Train 6   T=5.802  Decatur M Train 6.T=5.802
13   Decatur M Train 7       T=0      Decatur M Train 7.T=0
14   Decatur M Train 7   T=5.802  Decatur M Train 7.T=5.802
15   Decatur M Train 8       T=0      Decatur M Train 8.T=0
16   Decatur M Train 8   T=5.802  Decatur M Train 8.T=5.802
17   Decatur M Train 9       T=0      Decatur M Train 9.T=0
18   Decatur M Train 9   T=5.802  Decatur M Train 9.T=5.802
19  Decatur F Train 10       T=0     Decatur F Train 10.T=0
20  Decatur F Train 10   T=5.802 Decatur F Train 10.T=5.802
21  Decatur F Train 11       T=0     Decatur F Train 11.T=0
22  Decatur F Train 11   T=5.802 Decatur F Train 11.T=5.802
23  Decatur F Train 12       T=0     Decatur F Train 12.T=0
24  Decatur F Train 12   T=5.802 Decatur F Train 12.T=5.802
25  Decatur F Train 13       T=0     Decatur F Train 13.T=0
26  Decatur F Train 13   T=5.802 Decatur F Train 13.T=5.802
27  Decatur F Train 14       T=0     Decatur F Train 14.T=0
28  Decatur F Train 14   T=5.802 Decatur F Train 14.T=5.802
29  Decatur F Train 15       T=0     Decatur F Train 15.T=0
30  Decatur F Train 15   T=5.802 Decatur F Train 15.T=5.802
31  Decatur F Train 16       T=0     Decatur F Train 16.T=0
32  Decatur F Train 16   T=5.802 Decatur F Train 16.T=5.802
33  Decatur F Train 17       T=0     Decatur F Train 17.T=0
34  Decatur F Train 17   T=5.802 Decatur F Train 17.T=5.802
35  Decatur F Train 18       T=0     Decatur F Train 18.T=0
36  Decatur F Train 18   T=5.802 Decatur F Train 18.T=5.802
37   Decatur M Test 19       T=0      Decatur M Test 19.T=0
38   Decatur M Test 19   T=5.802  Decatur M Test 19.T=5.802
39   Decatur M Test 20       T=0      Decatur M Test 20.T=0
40   Decatur M Test 20   T=5.802  Decatur M Test 20.T=5.802
41   Decatur M Test 21       T=0      Decatur M Test 21.T=0
42   Decatur M Test 21   T=5.802  Decatur M Test 21.T=5.802
43   Decatur M Test 22       T=0      Decatur M Test 22.T=0
44   Decatur M Test 22   T=5.802  Decatur M Test 22.T=5.802
45   Decatur M Test 23       T=0      Decatur M Test 23.T=0
46   Decatur M Test 23   T=5.802  Decatur M Test 23.T=5.802
47   Decatur M Test 24       T=0      Decatur M Test 24.T=0
48   Decatur M Test 24   T=5.802  Decatur M Test 24.T=5.802
49   Decatur M Test 25       T=0      Decatur M Test 25.T=0
50   Decatur M Test 25   T=5.802  Decatur M Test 25.T=5.802
51   Decatur M Test 26       T=0      Decatur M Test 26.T=0
52   Decatur M Test 26   T=5.802  Decatur M Test 26.T=5.802
53   Decatur M Test 27       T=0      Decatur M Test 27.T=0
54   Decatur M Test 27   T=5.802  Decatur M Test 27.T=5.802
55   Decatur F Test 28       T=0      Decatur F Test 28.T=0
56   Decatur F Test 28   T=5.802  Decatur F Test 28.T=5.802
57   Decatur F Test 29       T=0      Decatur F Test 29.T=0
58   Decatur F Test 29   T=5.802  Decatur F Test 29.T=5.802
59   Decatur F Test 30       T=0      Decatur F Test 30.T=0
60   Decatur F Test 30   T=5.802  Decatur F Test 30.T=5.802
61   Decatur F Test 31       T=0      Decatur F Test 31.T=0
62   Decatur F Test 31   T=5.802  Decatur F Test 31.T=5.802
63   Decatur F Test 32       T=0      Decatur F Test 32.T=0
64   Decatur F Test 32   T=5.802  Decatur F Test 32.T=5.802
65   Decatur F Test 33       T=0      Decatur F Test 33.T=0
66   Decatur F Test 33   T=5.802  Decatur F Test 33.T=5.802
67   Decatur F Test 34       T=0      Decatur F Test 34.T=0
68   Decatur F Test 34   T=5.802  Decatur F Test 34.T=5.802
69   Decatur F Test 35       T=0      Decatur F Test 35.T=0
70   Decatur F Test 35   T=5.802  Decatur F Test 35.T=5.802
71   Decatur F Test 36       T=0      Decatur F Test 36.T=0
72   Decatur F Test 36   T=5.802  Decatur F Test 36.T=5.802
73   Decatur F Test 37       T=0      Decatur F Test 37.T=0
74   Decatur F Test 37   T=5.802  Decatur F Test 37.T=5.802
75  Paulsboro-Train 38     T=2.2   Paulsboro-Train 38.T=2.2
76    Horsham-Train 39       T=2       Horsham-Train 39.T=2
77  Warminster-Test 40       T=2     Warminster-Test 40.T=2
78 Warrington-Train 41       T=2    Warrington-Train 41.T=2
#Multicheck plot

# Split Steady State Group into different populations for boxplot grouping
#df_check[df_check$Time.desc == "SteadyState" & grepl("Lubeck",df_check$Dataset),]$Time.desc <- "Lubeck"
#df_check[df_check$Time.desc == "SteadyState" & grepl("Little Hocking",df_check$Dataset),]$Time.desc <- "Little Hocking"

Modify aesthetics lookup table for boxplots

##  additional source aesthetic lookup table for grey-scale time (years);  merged legends save space on plotting output
times <- df_check%>% select(Time.desc, Time) %>%  unique () %>% 
  mutate(rank = rank(Time) , grey = grey.colors(start=1,end=0.4, n = n()),
         alpha = (rank)/8) %>% 
  select(-Time)
 
df_check <- df_check %>% mutate (legend_label = (paste0(City, "\n", Time.desc ) )) # add legend-labels
aes_lut <- df_check %>% 
  select(City, Train_Test, datatype,Time, Time.desc, legend_label) %>% unique () %>%
   left_join(aes_lut[, c("City", "cols")], by = "City") %>% ungroup () %>% unique ()%>%
   left_join (times, by = "Time.desc") %>% 
   arrange(datatype, City, Train_Test, Time)    %>% 
   mutate(alpha = if_else(City == "Horsham", alpha/2, alpha)) %>% # otherwise too dark with this color
  mutate_if(is.factor, as.character) 

Decatur boxplots

Changed grey start to 1 instead of 0.8, end at 0.6 instead of 0.4. Changed shape of symbols so they are filled.

#GH
# Decatur 

df_decat  <- df_check %>%   
  filter(City == "Decatur" & Train_Test %in% c ("Train", "Test")) %>% 
  mutate(panel = ordered (Train_Test, levels = c ("Train", "Test"), 
                          labels = c("G: PFHxS Decatur Train", "H: PFHxS Decatur Test") ))

aes_lut_df_df_decat <- aes_lut %>% 
  filter(City == "Decatur" & Train_Test %in% c ("Train", "Test")) %>% 
  mutate_if(is.factor, as.character) 

source( paste0(gsub(basename(here()), 'shared_functions', here()), '/plot_sum_boxplot.r'))


plt_train <- plot_sum_boxplot   (dframe = df_decat, aes_lut= aes_lut_df_df_decat, facets = TRUE , pfas_nom = pfas_name     ) 
print(plt_train)

ggsave(here ("output-plots",paste0( sa,"DecaturTrainTestboxplot",pfas_name,".pdf")),plt_train,dpi=600)
Saving 6.5 x 3.5 in image

All boxplots

Changed grey start to 1 instead of 0.8, end at 0.6 instead of 0.4. Added shapes and fills to data points.

lets <- LETTERS;
names(lets)[1:(length(unique(df_check$dataset))-4)]<-as.character(unique(df_check$dataset))[5:length(unique(df_check$dataset))]

for (d in unique(df_check$dataset)) { # d = unique(df_check$dataset)[11]
    ddset <- df_check %>%    
    filter(dataset == d) 
    
    aes_lut_ddset <- ddset %>% select(legend_label,  City,Train_Test,datatype, Time.desc  ) %>% unique () %>% inner_join(aes_lut)
      
    gt <- ifelse(is.na(lets[d]),d,paste0(lets[d],": ", d))
    plt <- plot_sum_boxplot(dframe = ddset, aes_lut= aes_lut_ddset, gtitle= gt, facets = FALSE, pfas_nom = pfas_name)
     
  print(plt)
  ggsave(here ("output-plots",
                paste0( sa, d,"-boxplot-", 
                pfas_name,".pdf")) ,
         plt,dpi=600)

}
Joining, by = c("legend_label", "City", "Train_Test", "datatype", "Time.desc")
Warning: Column `City` joining factor and character vector, coercing into
character vector
Warning: Column `Train_Test` joining factor and character vector, coercing into
character vector
Saving 6.5 x 3.5 in image
Joining, by = c("legend_label", "City", "Train_Test", "datatype", "Time.desc")
Warning: Column `City` joining factor and character vector, coercing into
character vector

Warning: Column `Train_Test` joining factor and character vector, coercing into
character vector

Saving 6.5 x 3.5 in image
Joining, by = c("legend_label", "City", "Train_Test", "datatype", "Time.desc")
Warning: Column `City` joining factor and character vector, coercing into
character vector

Warning: Column `Train_Test` joining factor and character vector, coercing into
character vector

Saving 6.5 x 3.5 in image
Joining, by = c("legend_label", "City", "Train_Test", "datatype", "Time.desc")
Warning: Column `City` joining factor and character vector, coercing into
character vector

Warning: Column `Train_Test` joining factor and character vector, coercing into
character vector

Saving 6.5 x 3.5 in image
Joining, by = c("legend_label", "City", "Train_Test", "datatype", "Time.desc")
Warning: Column `City` joining factor and character vector, coercing into
character vector

Warning: Column `Train_Test` joining factor and character vector, coercing into
character vector

Saving 6.5 x 3.5 in image
Joining, by = c("legend_label", "City", "Train_Test", "datatype", "Time.desc")
Warning: Column `City` joining factor and character vector, coercing into
character vector

Warning: Column `Train_Test` joining factor and character vector, coercing into
character vector

Saving 6.5 x 3.5 in image
Joining, by = c("legend_label", "City", "Train_Test", "datatype", "Time.desc")
Warning: Column `City` joining factor and character vector, coercing into
character vector

Warning: Column `Train_Test` joining factor and character vector, coercing into
character vector

Saving 6.5 x 3.5 in image
Joining, by = c("legend_label", "City", "Train_Test", "datatype", "Time.desc")
Warning: Column `City` joining factor and character vector, coercing into
character vector

Warning: Column `Train_Test` joining factor and character vector, coercing into
character vector

Saving 6.5 x 3.5 in image

### make Training plot  

df_d_trt <- df_check %>%   
     filter( (Train_Test == "Train") & ((Output_Var == "M_Cbgd_Css") | (Output_Var == "M_Cserum"))) %>%
     mutate_if(is.factor, as.character) %>%  # drop factor levels unused
     mutate(Dataset.Time = factor(Dataset.Time)) 
 

 aes_lut_df_d_trt <-  df_d_trt %>% select(City, datatype,Time, Time.desc, legend_label) %>% 
   inner_join(aes_lut  ) %>% 
   select(-Train_Test) %>% ungroup () %>% unique ()  
Joining, by = c("City", "datatype", "Time", "Time.desc", "legend_label")
plt_train <-    plot_sum_boxplot(dframe = df_d_trt, aes_lut= aes_lut_df_d_trt,   
                                 gtitle="A: Summary Data - Train" , facets = FALSE, 
                                 pfas_nom = pfas_name )
  print(plt_train)

  ggsave(here ("output-plots", paste0( sa, "SummaryTrainDataboxplot",pfas_name,".pdf")), plt_train,dpi=600)
Saving 6.5 x 3.5 in image
###  make Test plot
df_d_test <- df_check %>%   
    filter((Train_Test == "Test") & 
             ((Output_Var == "M_Cbgd_Css") | (Output_Var == "M_Cserum")))  %>%
     mutate_if(is.factor, as.character) %>%  # drop factor levels unused
     mutate(Dataset.Time = factor(Dataset.Time)) 

aes_lut_df_d_test <-  df_d_test %>% select(City, datatype,Time, Time.desc, legend_label) %>% 
   inner_join(aes_lut  ) %>% 
   select(-Train_Test) %>% ungroup () %>% unique ()  
Joining, by = c("City", "datatype", "Time", "Time.desc", "legend_label")
plt_test <- plot_sum_boxplot(dframe = df_d_test, aes_lut= aes_lut_df_d_test, 
                             gtitle="B: Summary Data - Test", facets = FALSE, pfas_nom = pfas_name)
  print(plt_test)

  ggsave(here ("output-plots",paste0( sa, "SummaryTestDataboxplot",pfas_name,".pdf")), plt_test,dpi=600) 
Saving 6.5 x 3.5 in image

PFHxS

Background posteriors

Shows shift in background estimate.

gmscale<-0.8

dat <- multicheck$parms.samp[,grep("M_ln_Cbgd",names(multicheck$parms.samp))]
datasetnames <- as.character(unique(calibdata$dataset))
datasetnames <- gsub(" Train","-Train",datasetnames)
datasetnames <- gsub(" Test","-Train",datasetnames)
datasetnames <- gsub(" M","",datasetnames)
datasetnames <- gsub(" F","",datasetnames)
datasetnames<-datasetnames[!duplicated(datasetnames)]
datasetnames <- datasetnames[grep("Train",datasetnames)]
names(dat) <- datasetnames
dat <- dat[,grep("Train",names(dat))]
dat.df <- pivot_longer(dat,1:ncol(dat))
dat.df <- rbind(dat.df,
                data.frame(name="Prior",value=rnorm(5000,m=log(gmscale),sd=0.4055)))
dat.df$name <- factor(dat.df$name,levels=rev(
                        c("Prior",datasetnames[grep("Train",datasetnames)])))
dat.df$value <- exp(dat.df$value)

p<-ggplot(dat.df)+
 # geom_violin(aes(x=name,y=value,fill=name=="Prior"))+
  geom_boxplot(aes(x=name,y=value,fill=name=="Prior"),outlier.shape=NA)+
  scale_y_log10()+coord_flip()+
  scale_fill_manual(name=NULL, 
                    values=c("#009988", "#EE7733" )) +
  theme_classic() +  
  theme(axis.title.y.left = element_blank())+
  geom_hline(yintercept = gmscale, color="darkgrey", linetype = 2, size = 1.25)+
  theme(legend.position="none",
      panel.background = element_rect(color="black",size=1))+
  ylab("Posterior shift in Background Concentration")

print(p)

ggsave(here ("output-plots",paste0( sa, "PFHxS_GM_Cbgd.pdf")) ,p,dpi=600)
Saving 5 x 6 in image

Half-life

For PFHxS, the population GM of the half-life has a posterior distribution that is narrower than the prior, with a posterior median (95% CI) estimate of 3.06 (2.16-4.37) years. The population GSD posterior is larger than the prior at 1.47(1.44-1.75).

dat <- multicheck$parms.samp[,c("M_ln_k.1.","V_ln_k.1.", "M_ln_Vd.1.", "SD_ln_Vd.1.")]
names(dat) <- c("M_ln_k(1)","V_ln_k(1)", "M_ln_Vd(1)", "SD_ln_Vd(1)")
  
set.seed(3.14159)
dat$z_ln_k <- rnorm(nrow(dat))
dat$z_ln_Vd <- rnorm(nrow(dat))
dat %>% rename_()
dat$ln_k_i <- dat$`M_ln_k(1)` + sqrt(dat$`V_ln_k(1)`)*dat$z_ln_k
dat$ln_Vd_i <- dat$`M_ln_Vd(1)`+ dat$`SD_ln_Vd(1)`*dat$z_ln_Vd
linmod <- lm(ln_Vd_i ~ ln_k_i,data=dat)
ggplot(dat) + geom_point(aes(ln_k_i,ln_Vd_i)) + 
  labs(subtitle=paste("Adj R2 =",signif(summary(linmod)$adj.r.squared,2)))

Check normality

qqnorm(dat$ln_k_i,main="ln k Q-Q Normal")
qqline(dat$ln_k_i,col="red")

plot(ecdf(dat$ln_k_i))
x <- seq(-3,1,0.01)
m_ln_k_i <-   mean(dat$ln_k_i)
sd_ln_k_i <- sd(dat$ln_k_i)
lines(x,pnorm(x,mean=m_ln_k_i,sd=sd_ln_k_i),col="red")
text(m_ln_k_i-2*sd_ln_k_i,0.9,paste("m =",signif(m_ln_k_i,4),"\nsd =",signif(sd_ln_k_i,4)))

qqnorm(dat$ln_Vd_i,main="ln Vd Q-Q Normal")
qqline(dat$ln_Vd_i,col="red")

plot(ecdf(dat$ln_Vd_i))
x <- seq(-3,1,0.01)
m_ln_Vd_i <- mean(dat$ln_Vd_i)
sd_ln_Vd_i <- sd(dat$ln_Vd_i)

lines(x,pnorm(x,mean=m_ln_Vd_i,sd=sd_ln_Vd_i),col="red")
text(m_ln_Vd_i-2*sd_ln_Vd_i,0.9,paste("m =",signif(m_ln_Vd_i,4),"\nsd =",signif(sd_ln_Vd_i,4)))

Calculate table values for individual-level

hl_i <- log(2)/ exp(dat$ln_k_i) # individual half-life 
med_hl_i <- paste(signif (median (hl_i), 3)) # median of individual half-life
ci_med_hl_i <-   paste(signif (quantile(hl_i, prob=c(0.025,0.975)), 3),collapse="-") # 95ci med individual halflife
ci98_med_hl_i <-   paste(signif (quantile(hl_i, prob=c(0.01,0.99)), 3),collapse="-") # 98ci med individual halflife
gm_hl_i <- paste(signif (exp(mean(log(hl_i))), 3)) # gm (which should be really close)
gsd_hl_i <- paste(signif (exp(sd(log(hl_i))), 3)) # gsd individual

med_Vd_i <- paste(signif (median(exp(dat$ln_Vd_i)), 3)) # median individual Vd
ci_med_Vd_i <-paste(signif (quantile(exp(dat$ln_Vd_i), prob=c(0.025,0.975)), 3),collapse="-") # 95ci med individual Vd
ci98_med_Vd_i <-paste(signif (quantile(exp(dat$ln_Vd_i), prob=c(0.01,0.99)), 3),collapse="-") # 98ci med individual Vd
gm_vd_i <- paste(signif (exp(mean(dat$ln_Vd_i)), 3)) # gm (which should be really close)
gsd_vd_i<- paste(signif (exp(sd(dat$ln_Vd_i)), 3)) # gsd indiv
PFHxS_priors <- data.frame(
  halflife_GM= log(2)/rlnorm(50000,
                             meanlog=-2.03422,sdlog=0.4055))
M_k <- exp(as.numeric(dat$`M_ln_k(1)`))
PFHxS_halflife_GM <- log(2)/M_k

PFHxS_hlgm_pr_med <- signif(median(PFHxS_priors$halflife_GM,3))
PFHxS_hlgm_pr_med_95ci <-paste(signif(quantile(PFHxS_priors$halflife_GM,
                                            prob=c(0.025,0.975)),
                                   3),
                            collapse="-")

PFHxS_hl_median_gm <- signif(median(PFHxS_halflife_GM),3)
PFHxS_hl_median_gm_95ci <- paste(signif(quantile(PFHxS_halflife_GM,
                                            prob=c(0.025,0.975)),3),collapse="-")

p<-ggplot()+
  stat_density(aes(halflife_GM, color = "Prior"),data=PFHxS_priors,geom="line",size=2)+
  stat_density(aes(PFHxS_halflife_GM, stat(density),color="Posterior"),geom="line",size=1.5 )+
  xlim(0,15)+
  labs(title = bquote("G: PFHxS"~T[1/2]~"Population GM")  ,
       subtitle=paste("Posterior Median (95% CI): ",
                      PFHxS_hl_median_gm," (",
                      PFHxS_hl_median_gm_95ci,
                      ")",sep=""))+
  xlab(bquote("Population GM"~T[1/2]~"(yrs)")) +
  scale_color_manual(name=NULL,#
                    values=c(Prior="#009988", Posterior="#EE7733" )) + 
  theme_classic() +  
  theme(legend.title = element_blank(),legend.position=c(0.8,0.7),
      panel.background = element_rect(color="black",size=1),
      legend.background = element_rect(fill="transparent", color=NA))
print(p)
Warning: Removed 250 rows containing non-finite values (stat_density).
Warning: Removed 6 rows containing non-finite values (stat_density).

ggsave(here ("output-plots",paste0( sa, "PFHxS_hl_gm.pdf")),p,dpi=600)
Saving 4 x 2.5 in image
Warning: Removed 250 rows containing non-finite values (stat_density).

Warning: Removed 6 rows containing non-finite values (stat_density).
PFHxS_priors$halflife_GSD =  exp(sqrt(exp(rnorm(50000,m=log(0.2),sd=log(1.275))))) 
PFHxS_halflife_GSD <- exp(sqrt(dat$`V_ln_k(1)`))

PFHxS_hlgsd_pr_med <- signif(median(PFHxS_priors$halflife_GSD,3))
PFHxS_hlgsd_pr_med_95ci <-paste(signif(quantile(PFHxS_priors$halflife_GSD,
                                            prob=c(0.025,0.975)),
                                   3),
                            collapse="-")
PFHxS_hl_gsd_med <- signif(median(PFHxS_halflife_GSD),3)
PFHxS_hl_gsd_med_95ci <- paste(signif(quantile(PFHxS_halflife_GSD,
                                            prob=c(0.025,0.975)),3),collapse="-")
p<-ggplot()+
  stat_density(aes(halflife_GSD, color = "Prior"),data=PFHxS_priors,geom="line", size=2)+
  stat_density(aes(PFHxS_halflife_GSD,stat(density), color = "Posterior"),geom="line",size=1.5)+
  xlim(1,3)+
  labs(title = bquote("H: PFHxS"~T[1/2]~"Population GSD"),  
       subtitle=paste("Posterior Median (95% CI): ",
                      PFHxS_hl_gsd_med," (",
                      PFHxS_hl_gsd_med_95ci,
                      ")",sep=""))+
  xlab(bquote("Population GSD"~T[1/2]))+
  scale_color_manual(name=NULL,#
                    values=c(Prior="#009988", Posterior="#EE7733" )) + 
   theme_classic() +  
  theme(legend.title = element_blank(),legend.position=c(0.8,0.7),
      panel.background = element_rect(color="black",size=1),
      legend.background = element_rect(fill="transparent", color=NA))
print(p)

ggsave(here ("output-plots",paste0( sa, "PFHxS_hl_gsd.pdf")) ,p,dpi=600)

Volume of distribution

For PFHxS, the data were not particularly informative, but slightly increased the estimate of the median to 0.308(0.223-0.548) slightly compared to the case where Cbgd was considered to be entirely from non-drinking water sources. They were not informative as to the population GSD, with the posterior distributions essentially unchanged from the priors.

PFHxS_priors$Vd_GM <- rlnorm(50000,
                             meanlog=-1.38629,
                             sdlog=0.2624)
PFHxS_Vd_GM <- exp(dat$`M_ln_Vd(1)`)

 

PFHxS_vd_gm_pr_med <- signif(median(PFHxS_priors$Vd_GM,3))
PFHxS_vd_gm_pr_med_95ci <- paste(signif(quantile(PFHxS_priors$Vd_GM,
                                            prob=c(0.025,0.975)), 3), collapse="-")
PFHxS_vd_gm_med <- signif(median(PFHxS_Vd_GM),3)
PFHxS_vd_gm_med_95ci <- paste(signif(quantile(PFHxS_Vd_GM,
                                            prob=c(0.025,0.975)),3),collapse="-")

p<-ggplot()+
  stat_density(aes(Vd_GM, color = "Prior"),data=PFHxS_priors,geom="line",size=2)+
  stat_density(aes(PFHxS_Vd_GM,stat(density), color = "Posterior"),geom="line",size=1.5)+
  xlim(0,1)+labs(title = bquote("G: PFHxS"~V[d]~"Population GM"),
                 subtitle=paste("Posterior Median (95% CI): ",
                                PFHxS_vd_gm_med," (", 
                                PFHxS_vd_gm_med_95ci,")",sep=""))+
   xlab(bquote("Population GM"~V[d]~"(l/kg)"))+
  scale_color_manual(name=NULL,#
                    values=c(Prior="#009988", Posterior="#EE7733" )) +  
  theme_classic() +  
  theme(legend.title = element_blank(),legend.position=c(0.8,0.7),
      panel.background = element_rect(color="black",size=1),
      legend.background = element_rect(fill="transparent", color=NA))
print(p)

ggsave(here ("output-plots",paste0( sa, "PFHxS_vd_gm.pdf")) ,p,dpi=600)
PFHxS_priors$Vd_GSD = exp(abs(rnorm(50000,sd=0.17)))
PFHxS_Vd_GSD <- exp(dat$`SD_ln_Vd(1)`)

PFHxS_vd_gsd_pr_med <- signif(median(PFHxS_priors$Vd_GSD,3))
PFHxS_vd_gsd_pr_med_95ci <- paste(signif(quantile(PFHxS_priors$Vd_GSD,
                                            prob=c(0.025,0.975)), 3), collapse="-")

PFHxS_vd_gsd_med <- signif(median(PFHxS_Vd_GSD),3)
PFHxS_vd_gsd_med_95ci <- paste(signif(quantile(PFHxS_Vd_GSD,
                                            prob=c(0.025,0.975)),3),collapse="-")

p<-ggplot()+
  stat_density(aes(Vd_GSD, color = "Prior"),data=PFHxS_priors,geom="line",size=2)+
  stat_density(aes(PFHxS_Vd_GSD,stat(density), color = "Posterior"),geom="line",size=1.5)+
  xlim(1,3)+
  labs(title = bquote("H: PFHxS"~V[d]~"Population GSD "),
       subtitle=paste("Posterior Median (95% CI): ",
                      PFHxS_vd_gsd_med," (",
                      PFHxS_vd_gsd_med_95ci,
                      ")",sep=""))+
  xlab(bquote("Population GSD"~V[d]))+
  scale_color_manual(name=NULL, 
                     values=c(Prior="#009988", Posterior="#EE7733" )) + 
  theme_classic() +  
  theme(legend.title = element_blank(),legend.position=c(0.8,0.7),
      panel.background = element_rect(color="black",size=1),
      legend.background = element_rect(fill="transparent", color=NA))
print(p)

ggsave(here ("output-plots",paste0( sa,"PFHxS_vd_gsd.pdf")) ,p,dpi=600)

Clearance (just pop GM)

Cl is k * Vd

PFHxS_priors$CL_GM <- PFHxS_priors$Vd_GM * (log(2)/PFHxS_priors$halflife_GM)
PFHxS_CL_GM <- exp(dat$`M_ln_Vd(1)` + dat$`M_ln_k(1)`)

PFHxS_cl_gm_pr_med <- signif(median(PFHxS_priors$CL_GM,3))
PFHxS_cl_gm_pr_med_95ci <- paste(signif(quantile(PFHxS_priors$CL_GM,
                                            prob=c(0.025,0.975)), 3), collapse="-")
PFHxS_cl_gm_med <- signif(median(PFHxS_CL_GM),3)
PFHxS_cl_gm_med_95ci <- paste(signif(quantile(PFHxS_CL_GM,
                                            prob=c(0.025,0.975)),3),collapse="-")

p<-ggplot()+
  stat_density(aes(CL_GM, color = "Prior"),data=PFHxS_priors,geom="line",size=2)+
  stat_density(aes(PFHxS_CL_GM,stat(density), color = "Posterior"),geom="line",size=1.5)+
  xlim(0,0.25)+labs(title = "D: PFHxS Clearance Pop. GM ",subtitle=paste("Posterior Median (95% CI): ",
                                                                    PFHxS_cl_gm_med," (",
                                                                    PFHxS_cl_gm_med_95ci,
                                                                    ")",sep=""))+
  xlab("Pop. GM CL (l/(kg-yr))")+
  scale_color_manual(name=NULL,#
                    values=c(Prior="#009988", Posterior="#EE7733" )) +  
  theme_classic() +  
  theme(legend.title = element_blank(),legend.position=c(0.8,0.7),
      panel.background = element_rect(color="black",size=1),
      legend.background = element_rect(fill="transparent", color=NA))
print(p)

ggsave(here ("output-plots",paste0( sa, "PFHxS_CL_gm.pdf")), p,dpi=600)

Table significant digit values

PFHxS_hlgm_pr_med <- paste(signif(PFHxS_hlgm_pr_med, 3))
PFHxS_hl_median_gm<- paste(signif(PFHxS_hl_median_gm, 3))
PFHxS_hlgsd_pr_med<- paste(signif(PFHxS_hlgsd_pr_med, 3))
PFHxS_hl_gsd_med<- paste(signif(PFHxS_hl_gsd_med, 3))
PFHxS_vd_gm_pr_med<- paste(signif(PFHxS_vd_gm_pr_med, 3))
PFHxS_vd_gm_med<- paste(signif(PFHxS_vd_gm_med, 3))
PFHxS_vd_gsd_pr_med<- paste(signif(PFHxS_vd_gsd_pr_med, 3))
PFHxS_vd_gsd_med<- paste(signif(PFHxS_vd_gsd_med, 3))
PFHxS_cl_gm_pr_med<- paste(signif(PFHxS_cl_gm_pr_med, 3))
PFHxS_cl_gm_med<- paste(signif(PFHxS_cl_gm_med, 3))

Population median estimates [95% CI]

Parameter Prior GM Posterior GM Prior GSD Posterior GSD
Half-life (years) 5.29 8.3 1.56 1.57
HL [95% CI] [2.39-11.8] [5.38-13.5] [1.42-1.77] [1.42-1.77]
Volume of distribution 0.25 0.286 1.12 1.11
\(V_D\) [95% CI] [0.149-0.418] [0.173-0.456] [1.01-1.46] [1-1.45]
Clearance 0.0326 0.0246
\(CL\) [95% CI] [0.0126-0.0847] [0.0121-0.0393] [] []

Individual Posterior estimates

Parameter median GM [95% CI] [[98% CI]] GM calculator input GSD individual
Half-life (years) 8.12 [ 2.79-21.6 ] [[ 2.19-24.8 ]] 8.2 1.68
Volume of distribution \(V_D\) 0.281 [ 0.161-0.46 ] [[ 0.14-0.561 ]] 0.281 1.32

Session information

─ Session info ───────────────────────────────────────────────────────────────
 setting  value                       
 version  R version 3.6.1 (2019-07-05)
 os       Oracle Linux Server 7.9     
 system   x86_64, linux-gnu           
 ui       X11                         
 language (EN)                        
 collate  en_US.UTF-8                 
 ctype    en_US.UTF-8                 
 tz       America/New_York            
 date     2021-03-28                  

─ Packages ───────────────────────────────────────────────────────────────────
 package     * version date       lib source        
 assertthat    0.2.1   2019-03-21 [2] CRAN (R 3.6.1)
 backports     1.1.5   2019-10-02 [2] CRAN (R 3.6.1)
 base64enc     0.1-3   2015-07-28 [2] CRAN (R 3.6.1)
 bayesplot   * 1.7.0   2019-05-23 [2] CRAN (R 3.6.1)
 broom         0.5.2   2019-04-07 [2] CRAN (R 3.6.1)
 callr         3.3.2   2019-09-22 [2] CRAN (R 3.6.1)
 cellranger    1.1.0   2016-07-27 [2] CRAN (R 3.6.1)
 cli           1.1.0   2019-03-19 [2] CRAN (R 3.6.1)
 coda        * 0.19-3  2019-07-05 [2] CRAN (R 3.6.1)
 codetools     0.2-16  2018-12-24 [2] CRAN (R 3.6.1)
 colorspace    1.4-1   2019-03-18 [2] CRAN (R 3.6.1)
 crayon        1.3.4   2017-09-16 [2] CRAN (R 3.6.1)
 DBI           1.0.0   2018-05-02 [2] CRAN (R 3.6.1)
 dbplyr        1.4.2   2019-06-17 [2] CRAN (R 3.6.1)
 desc          1.2.0   2018-05-01 [2] CRAN (R 3.6.1)
 devtools      2.2.1   2019-09-24 [2] CRAN (R 3.6.1)
 digest        0.6.23  2019-11-23 [2] CRAN (R 3.6.1)
 dplyr       * 0.8.3   2019-07-04 [2] CRAN (R 3.6.1)
 ellipsis      0.3.0   2019-09-20 [2] CRAN (R 3.6.1)
 evaluate      0.14    2019-05-28 [2] CRAN (R 3.6.1)
 farver        2.0.1   2019-11-13 [2] CRAN (R 3.6.1)
 forcats     * 0.4.0   2019-02-17 [2] CRAN (R 3.6.1)
 fs            1.3.1   2019-05-06 [2] CRAN (R 3.6.1)
 generics      0.0.2   2018-11-29 [2] CRAN (R 3.6.1)
 ggplot2     * 3.2.1   2019-08-10 [2] CRAN (R 3.6.1)
 ggridges      0.5.1   2018-09-27 [2] CRAN (R 3.6.1)
 ggsci       * 2.9     2018-05-14 [2] CRAN (R 3.6.1)
 glue          1.3.1   2019-03-12 [2] CRAN (R 3.6.1)
 gtable        0.3.0   2019-03-25 [2] CRAN (R 3.6.1)
 haven         2.2.0   2019-11-08 [2] CRAN (R 3.6.1)
 here        * 0.1     2017-05-28 [2] CRAN (R 3.6.1)
 hms           0.5.2   2019-10-30 [2] CRAN (R 3.6.1)
 htmltools     0.4.0   2019-10-04 [2] CRAN (R 3.6.1)
 httr          1.4.1   2019-08-05 [2] CRAN (R 3.6.1)
 jsonlite      1.6     2018-12-07 [2] CRAN (R 3.6.1)
 khroma      * 1.4.0   2020-10-05 [1] CRAN (R 3.6.1)
 knitr         1.26    2019-11-12 [2] CRAN (R 3.6.1)
 labeling      0.3     2014-08-23 [2] CRAN (R 3.6.1)
 lattice       0.20-38 2018-11-04 [2] CRAN (R 3.6.1)
 lazyeval      0.2.2   2019-03-15 [2] CRAN (R 3.6.1)
 lifecycle     0.1.0   2019-08-01 [2] CRAN (R 3.6.1)
 lubridate     1.7.4   2018-04-11 [2] CRAN (R 3.6.1)
 magrittr      1.5     2014-11-22 [2] CRAN (R 3.6.1)
 memoise       1.1.0   2017-04-21 [2] CRAN (R 3.6.1)
 modelr        0.1.5   2019-08-08 [2] CRAN (R 3.6.1)
 munsell       0.5.0   2018-06-12 [2] CRAN (R 3.6.1)
 nlme          3.1-142 2019-11-07 [2] CRAN (R 3.6.1)
 pillar        1.4.2   2019-06-29 [2] CRAN (R 3.6.1)
 pkgbuild      1.0.6   2019-10-09 [2] CRAN (R 3.6.1)
 pkgconfig     2.0.3   2019-09-22 [2] CRAN (R 3.6.1)
 pkgload       1.0.2   2018-10-29 [2] CRAN (R 3.6.1)
 plyr          1.8.4   2016-06-08 [2] CRAN (R 3.6.1)
 prettyunits   1.0.2   2015-07-13 [2] CRAN (R 3.6.1)
 processx      3.4.1   2019-07-18 [2] CRAN (R 3.6.1)
 ps            1.3.0   2018-12-21 [2] CRAN (R 3.6.1)
 purrr       * 0.3.3   2019-10-18 [2] CRAN (R 3.6.1)
 R6            2.4.1   2019-11-12 [2] CRAN (R 3.6.1)
 Rcpp          1.0.3   2019-11-08 [2] CRAN (R 3.6.1)
 readr       * 1.3.1   2018-12-21 [2] CRAN (R 3.6.1)
 readxl        1.3.1   2019-03-13 [2] CRAN (R 3.6.1)
 remotes       2.1.0   2019-06-24 [2] CRAN (R 3.6.1)
 reprex        0.3.0   2019-05-16 [2] CRAN (R 3.6.1)
 reshape2    * 1.4.3   2017-12-11 [2] CRAN (R 3.6.1)
 rlang         0.4.2   2019-11-23 [2] CRAN (R 3.6.1)
 rmarkdown     1.18    2019-11-27 [2] CRAN (R 3.6.1)
 rprojroot     1.3-2   2018-01-03 [2] CRAN (R 3.6.1)
 rstudioapi    0.10    2019-03-19 [2] CRAN (R 3.6.1)
 rvest         0.3.5   2019-11-08 [2] CRAN (R 3.6.1)
 scales        1.1.0   2019-11-18 [2] CRAN (R 3.6.1)
 sessioninfo   1.1.1   2018-11-05 [2] CRAN (R 3.6.1)
 stringi       1.4.3   2019-03-12 [2] CRAN (R 3.6.1)
 stringr     * 1.4.0   2019-02-10 [2] CRAN (R 3.6.1)
 testthat      2.3.0   2019-11-05 [2] CRAN (R 3.6.1)
 tibble      * 2.1.3   2019-06-06 [2] CRAN (R 3.6.1)
 tidyr       * 1.0.0   2019-09-11 [2] CRAN (R 3.6.1)
 tidyselect    0.2.5   2018-10-11 [2] CRAN (R 3.6.1)
 tidyverse   * 1.3.0   2019-11-21 [2] CRAN (R 3.6.1)
 usethis       1.5.1   2019-07-04 [2] CRAN (R 3.6.1)
 vctrs         0.2.0   2019-07-05 [2] CRAN (R 3.6.1)
 withr         2.1.2   2018-03-15 [2] CRAN (R 3.6.1)
 xfun          0.11    2019-11-12 [2] CRAN (R 3.6.1)
 xml2          1.2.2   2019-08-09 [2] CRAN (R 3.6.1)
 yaml          2.2.0   2018-07-25 [2] CRAN (R 3.6.1)
 zeallot       0.1.0   2018-01-28 [2] CRAN (R 3.6.1)

[1] /home/ad.abt.local/wchiu/R/library
[2] /opt/R/3.6.1/lib64/R/library
---
title: "PFHxS 1 compartment Plots (v8)"
author: "Weihsueh Chiu, Claire Lay, Parker Malek"
date: "`r format(Sys.time(), '%F')`"
knit: (function(inputFile, encoding) {outdir = file.path(dirname(inputFile), 'markdown', paste0(format(Sys.time(), '%F'))); if(!dir.exists(outdir)){dir.create(outdir)}; rmarkdown::render(inputFile, encoding = encoding, output_format = 'all', output_dir = outdir) })
output:
  word_document: default
  html_notebook:
    code_folding: hide
    df_print: kable
    toc: yes
    toc_depth: 5
---

```{r setup}
library(coda)
library(bayesplot) 
library(ggplot2)
library(ggsci)
library(khroma)
library(tidyverse)
library(reshape2)
library(here)
knitr::opts_chunk$set(echo = TRUE, dpi = 300 )
```

Set up MCSim file

```{r mcsim}
# this markdown file must be saved in top level directory for the following to work; the mcsim code depends on getwd results.
mdir <- "MCSim"
source(here::here(mdir,"setup_MCSim.R"))
# Make mod.exe (used to create mcsim executable from model file)
makemod() 
```

## Set filenames and load data


```{r MCMC  model file, include=FALSE}
set.seed(314159)
sa <- "Cbgd-80_" # ADD sensitivity test tag to plot filenames
# M_ln_Cbgd_sc to be centered on ln(0.8) instead of 0 (decreased by 20%)
# Make model executable
model_file<- "PFAS_1cpt_v8.pop.MCMC.model.R"
makemcsim(model_file)

in_file <- "PFHxS_1cpt_v8.PopMCMC_MeanIndivTrainTest.in.R" 
pfas_name <- gsub("_1cpt_v8.PopMCMC_MeanIndivTrainTest.in.R", "", in_file)

samps <- data.frame()
checks <- data.frame()
samps.list <- list()
for (chainnum in 1:4) {
  onechain <- read.delim(sub(".in.R",paste0(chainnum,".out"),in_file))
  samps.list[[chainnum]]<-mcmc(onechain[floor(nrow(onechain) / 2):nrow(onechain), -1])
  samps <- rbind(samps,samps.list[[chainnum]])
  onecheck <- read.delim(sub(".in.R",paste0(chainnum,".check.out"),in_file))
  onecheck$Chain <- chainnum
  checks <- rbind(checks,onecheck)
}
samps.mcmclist <- as.mcmc.list(samps.list)

load("PFHxS_1cpt_v8_multicheck.Rdata") 
```

## Set up dataset

```{r dataset-LUT, cache = TRUE}
id_lut <- multicheck$df_check %>% select(Level) %>% unique ()  %>%
  mutate(dataset = c( 
    rep("Decatur M Train", 9),
    rep("Decatur F Train", 9),
    rep("Decatur M Test", 9),
    rep("Decatur F Test", 10),
    'Paulsboro-Train','Horsham-Train',
    'Warminster-Test','Warrington-Train'), 
    Sex = c( 
    rep("M", 9),
    rep("F", 9),
    rep("M", 9),
    rep("F", 10),
    'Mixed', 'Mixed',  'Mixed', 'Mixed'),
    City = c( 
    rep("Decatur", 18),
    rep("Decatur", 19),
    'Paulsboro','Horsham','Warminster','Warrington'), 
    Train_Test = c( 
    rep("Train", 9),
    rep("Train", 9),
    rep("Test", 9),
    rep("Test", 10),
    'Train', 'Train', 'Test', 'Test'),
    datatype = c(
      rep("Individual",9+9+9+10),
      rep("Summary",4)),
    Simulation = row_number(),
    variable = paste0(dataset, " ",Simulation))

id_lut$dataset <- factor(id_lut$dataset,levels=
                           c("Decatur M Train","Decatur F Train","Arnsberg M Train",
                             "Arnsberg F Train","Decatur M Test","Decatur F Test","Arnsberg M Test",
                             "Arnsberg F Test","Minnesota Train","Minnesota Test",
                             'Lubeck-Bartell-Train', 'Lubeck-Bartell-Test',
                             'Little Hocking-Bartell-Train', 'Little Hocking-Bartell-Test',
                             'Little Hocking-Emmett-Test','Paulsboro-Train','Horsham-Train',
                             'Warminster-Test','Warrington-Train'))
id_lut$City <- factor(id_lut$City,levels = 
                        c("Decatur","Arnsberg","Minnesota",'Lubeck-Bartell',
                          'Little Hocking-Bartell','Little Hocking-Emmett',
                          'Paulsboro','Horsham','Warminster','Warrington'))
 

indiv_lut <- id_lut %>% 
  filter(City %in% c("Decatur")) %>%
  mutate(  dataset = as.factor(dataset))

nv <- data.frame(dataset =unique(indiv_lut$dataset), 
           variable= rep("Pop GM", 4),
           type= rep("Pop GM", 4), stringsAsFactors = FALSE)
```


## Scatter plot of predictions (median of multicheck samples) versus data.

This is a Figure 2 panel.  Needed to use "scale=1.1" in ggsave to match PFOA.

```{r prediction-versus-data , cache = TRUE,fig.height=3.5,fig.width=8,dpi=600}
nrow(multicheck$df_check)
nrow(id_lut)
multicheck$df_check %>% left_join(id_lut) %>% nrow()

names(multicheck$df_check)

multicheck2 <- multicheck$df_check %>% 
  left_join(id_lut, by = c("Level", "Simulation"))%>% 
  group_by_at ( vars(-Prediction)) %>% 
  summarise(Prediction = median(Prediction)) %>%
  ungroup() %>%
  group_by(City) %>% 
  mutate(Train_Test = factor(Train_Test, levels = c("Train", "Test")),
         `City (datatype)` = factor (paste0(City, "\n(", datatype, ")\n") ),
         label = case_when(Train_Test=="Train" ~ "G: PFHxS Train",
                           Train_Test=="Test"  ~ "H: PFHxS Test",
                           TRUE ~ ""))
 
#define color for testing boxplots
bp_cols <- c (as.character (khroma::colour("muted")(9)) , "#191919")   
bp_cols <-bp_cols[c(1,7,10:8)]# plot_scheme_colourblind(bp_cols) 

### Create aesthetics lookup
aes_lut <- multicheck2 %>% ungroup() %>% 
  group_by(City, datatype,  `City (datatype)` ) %>% summarise () %>% ungroup() %>%
  mutate( cols = bp_cols, city_fills =   bp_cols , 
          # for individual level on point plot (multicheck2), darken outlines for visibility, use standard colors otherwise
         city_outlines =  if_else(datatype == "Individual"  ,  colorspace::darken(city_fills, 0.3), city_fills) ,  
         shapes = case_when(datatype == "Individual"  & `City` %in% c('Decatur', 'Arnsberg', 'Minnesota')   ~  23,
                            datatype == "Summary" &`City` %in% c("Horsham", "Warminster",  "Warrington") ~ 2,
                            datatype == "Summary" & `City` == "Paulsboro" ~ 1,
                            TRUE ~ 18                                ), 
         size = if_else(datatype =="Individual", 1.75, 2.5 ) )  



source( paste0(gsub(basename(here()), 'shared_functions', here()), '/plot_scatter_mcheck.r'))

p2 <- plot_scatter_mcheck(dframe = multicheck2,  pfas_nom = pfas_name, aes_lut_fn = aes_lut )
print(p2) 
ggsave(here ("output-plots", paste0( sa,"multicheckplot_", pfas_name,
               ".pdf")),p2,dpi=600, scale=1.1)

```

## Parse multicheck

```{r do-multicheck, cache = TRUE, fig.width=6, fig.height=18}

df_check <- multicheck$df_check
df_check <- subset(df_check,Data > 0) 

n1 <- nrow(df_check)
id_chks <- df_check %>% select(Level) %>% unique() %>% bind_cols(id_lut)  %>%
  mutate(dataset = as.factor(dataset), Sex = as.factor(Sex), City = as.factor(City), 
         Train_Test = as.factor(Train_Test))

df_check <- df_check %>% left_join(id_chks)%>%
  mutate(Dataset = paste(as.character(dataset), Simulation),
         Sex = ordered(Sex, levels = c("M", "F", "Mixed"), 
                       labels = c("Male", "Female", "Mixed (all sexes)")))
n2 <- nrow(df_check)
if(n1 != n2)print("duplicates created in id-lut join")
```


```{r do-multicheck-2, cache = TRUE, fig.width=6, fig.height=18}
df_check$Time.desc <- as.character(paste0("T=",df_check$Time))
df_check$Time.desc[df_check$Time.desc == "T=1e-06"] <- "SteadyState"
df_check$Dataset.Time <- interaction(df_check$Dataset,
                                     df_check$Time.desc,lex.order=TRUE)
df_check$Dataset.Time <- factor(df_check$Dataset.Time,
                                levels=levels(df_check$Dataset.Time))
calibdata <- df_check[,names(df_check) != "Prediction"]
calibdata <- calibdata[!duplicated(calibdata),]
print(calibdata)
 
#Multicheck plot

# Split Steady State Group into different populations for boxplot grouping
#df_check[df_check$Time.desc == "SteadyState" & grepl("Lubeck",df_check$Dataset),]$Time.desc <- "Lubeck"
#df_check[df_check$Time.desc == "SteadyState" & grepl("Little Hocking",df_check$Dataset),]$Time.desc <- "Little Hocking"
```
Modify aesthetics lookup table for boxplots 
```{r mod-aes-lut}
##  additional source aesthetic lookup table for grey-scale time (years);  merged legends save space on plotting output
times <- df_check%>% select(Time.desc, Time) %>%  unique () %>% 
  mutate(rank = rank(Time) , grey = grey.colors(start=1,end=0.4, n = n()),
         alpha = (rank)/8) %>% 
  select(-Time)
 
df_check <- df_check %>% mutate (legend_label = (paste0(City, "\n", Time.desc ) )) # add legend-labels
aes_lut <- df_check %>% 
  select(City, Train_Test, datatype,Time, Time.desc, legend_label) %>% unique () %>%
   left_join(aes_lut[, c("City", "cols")], by = "City") %>% ungroup () %>% unique ()%>%
   left_join (times, by = "Time.desc") %>% 
   arrange(datatype, City, Train_Test, Time)    %>% 
   mutate(alpha = if_else(City == "Horsham", alpha/2, alpha)) %>% # otherwise too dark with this color
  mutate_if(is.factor, as.character) 

```

## Decatur boxplots

Changed grey start to 1 instead of 0.8, end at 0.6 instead of 0.4.
Changed shape of symbols so they are filled.

```{r do-multicheck-decatur, cache = TRUE, fig.width=6.5, fig.height=3.5,dpi=600}
#GH
# Decatur 

df_decat  <- df_check %>%   
  filter(City == "Decatur" & Train_Test %in% c ("Train", "Test")) %>% 
  mutate(panel = ordered (Train_Test, levels = c ("Train", "Test"), 
                          labels = c("G: PFHxS Decatur Train", "H: PFHxS Decatur Test") ))

aes_lut_df_df_decat <- aes_lut %>% 
  filter(City == "Decatur" & Train_Test %in% c ("Train", "Test")) %>% 
  mutate_if(is.factor, as.character) 

source( paste0(gsub(basename(here()), 'shared_functions', here()), '/plot_sum_boxplot.r'))


plt_train <- plot_sum_boxplot   (dframe = df_decat, aes_lut= aes_lut_df_df_decat, facets = TRUE , pfas_nom = pfas_name     ) 
print(plt_train)
ggsave(here ("output-plots",paste0( sa,"DecaturTrainTestboxplot",pfas_name,".pdf")),plt_train,dpi=600)
  
```

## All boxplots

Changed grey start to 1 instead of 0.8, end at 0.6 instead of 0.4.
Added shapes and fills to data points.

```{r do-multicheck-all, cache = TRUE, fig.width=6.5, fig.height=3.5,dpi=600}

lets <- LETTERS;
names(lets)[1:(length(unique(df_check$dataset))-4)]<-as.character(unique(df_check$dataset))[5:length(unique(df_check$dataset))]

for (d in unique(df_check$dataset)) { # d = unique(df_check$dataset)[11]
    ddset <- df_check %>%    
    filter(dataset == d) 
    
    aes_lut_ddset <- ddset %>% select(legend_label,  City,Train_Test,datatype, Time.desc  ) %>% unique () %>% inner_join(aes_lut)
      
    gt <- ifelse(is.na(lets[d]),d,paste0(lets[d],": ", d))
    plt <- plot_sum_boxplot(dframe = ddset, aes_lut= aes_lut_ddset, gtitle= gt, facets = FALSE, pfas_nom = pfas_name)
     
  print(plt)
  ggsave(here ("output-plots",
                paste0( sa, d,"-boxplot-", 
                pfas_name,".pdf")) ,
         plt,dpi=600)

}

### make Training plot  

df_d_trt <- df_check %>%   
     filter( (Train_Test == "Train") & ((Output_Var == "M_Cbgd_Css") | (Output_Var == "M_Cserum"))) %>%
     mutate_if(is.factor, as.character) %>%  # drop factor levels unused
     mutate(Dataset.Time = factor(Dataset.Time)) 
 

 aes_lut_df_d_trt <-  df_d_trt %>% select(City, datatype,Time, Time.desc, legend_label) %>% 
   inner_join(aes_lut  ) %>% 
   select(-Train_Test) %>% ungroup () %>% unique ()  

plt_train <-    plot_sum_boxplot(dframe = df_d_trt, aes_lut= aes_lut_df_d_trt,   
                                 gtitle="A: Summary Data - Train" , facets = FALSE, 
                                 pfas_nom = pfas_name )
  print(plt_train)
  ggsave(here ("output-plots", paste0( sa, "SummaryTrainDataboxplot",pfas_name,".pdf")), plt_train,dpi=600)

###  make Test plot
df_d_test <- df_check %>%   
    filter((Train_Test == "Test") & 
             ((Output_Var == "M_Cbgd_Css") | (Output_Var == "M_Cserum")))  %>%
     mutate_if(is.factor, as.character) %>%  # drop factor levels unused
     mutate(Dataset.Time = factor(Dataset.Time)) 

aes_lut_df_d_test <-  df_d_test %>% select(City, datatype,Time, Time.desc, legend_label) %>% 
   inner_join(aes_lut  ) %>% 
   select(-Train_Test) %>% ungroup () %>% unique ()  

plt_test <- plot_sum_boxplot(dframe = df_d_test, aes_lut= aes_lut_df_d_test, 
                             gtitle="B: Summary Data - Test", facets = FALSE, pfas_nom = pfas_name)
  print(plt_test)
  ggsave(here ("output-plots",paste0( sa, "SummaryTestDataboxplot",pfas_name,".pdf")), plt_test,dpi=600) 
```

## PFHxS
### Background posteriors

Shows shift in background estimate.

```{r get background, cache = TRUE,fig.height=6,fig.width=5,dpi=600}

gmscale<-0.8

dat <- multicheck$parms.samp[,grep("M_ln_Cbgd",names(multicheck$parms.samp))]
datasetnames <- as.character(unique(calibdata$dataset))
datasetnames <- gsub(" Train","-Train",datasetnames)
datasetnames <- gsub(" Test","-Train",datasetnames)
datasetnames <- gsub(" M","",datasetnames)
datasetnames <- gsub(" F","",datasetnames)
datasetnames<-datasetnames[!duplicated(datasetnames)]
datasetnames <- datasetnames[grep("Train",datasetnames)]
names(dat) <- datasetnames
dat <- dat[,grep("Train",names(dat))]
dat.df <- pivot_longer(dat,1:ncol(dat))
dat.df <- rbind(dat.df,
                data.frame(name="Prior",value=rnorm(5000,m=log(gmscale),sd=0.4055)))
dat.df$name <- factor(dat.df$name,levels=rev(
                        c("Prior",datasetnames[grep("Train",datasetnames)])))
dat.df$value <- exp(dat.df$value)

p<-ggplot(dat.df)+
 # geom_violin(aes(x=name,y=value,fill=name=="Prior"))+
  geom_boxplot(aes(x=name,y=value,fill=name=="Prior"),outlier.shape=NA)+
  scale_y_log10()+coord_flip()+
  scale_fill_manual(name=NULL, 
                    values=c("#009988", "#EE7733" )) +
  theme_classic() +  
  theme(axis.title.y.left = element_blank())+
  geom_hline(yintercept = gmscale, color="darkgrey", linetype = 2, size = 1.25)+
  theme(legend.position="none",
      panel.background = element_rect(color="black",size=1))+
  ylab("Posterior shift in Background Concentration")

print(p)
ggsave(here ("output-plots",paste0( sa, "PFHxS_GM_Cbgd.pdf")) ,p,dpi=600)

```

### Half-life

For PFHxS, the population GM of the half-life has a posterior distribution that is narrower than the prior, with a posterior median (95% CI) estimate of 3.06 (2.16-4.37) years. The population GSD posterior is larger than the prior at 1.47(1.44-1.75).

```{r posterior histograms, cache = TRUE}


dat <- multicheck$parms.samp[,c("M_ln_k.1.","V_ln_k.1.", "M_ln_Vd.1.", "SD_ln_Vd.1.")]
names(dat) <- c("M_ln_k(1)","V_ln_k(1)", "M_ln_Vd(1)", "SD_ln_Vd(1)")
  
set.seed(3.14159)
dat$z_ln_k <- rnorm(nrow(dat))
dat$z_ln_Vd <- rnorm(nrow(dat))
dat %>% rename_()
dat$ln_k_i <- dat$`M_ln_k(1)` + sqrt(dat$`V_ln_k(1)`)*dat$z_ln_k
dat$ln_Vd_i <- dat$`M_ln_Vd(1)`+ dat$`SD_ln_Vd(1)`*dat$z_ln_Vd
linmod <- lm(ln_Vd_i ~ ln_k_i,data=dat)
ggplot(dat) + geom_point(aes(ln_k_i,ln_Vd_i)) + 
  labs(subtitle=paste("Adj R2 =",signif(summary(linmod)$adj.r.squared,2)))
```


## Check normality

```{r normality, cache = TRUE}

qqnorm(dat$ln_k_i,main="ln k Q-Q Normal")
qqline(dat$ln_k_i,col="red")
plot(ecdf(dat$ln_k_i))
x <- seq(-3,1,0.01)
m_ln_k_i <-   mean(dat$ln_k_i)
sd_ln_k_i <- sd(dat$ln_k_i)
lines(x,pnorm(x,mean=m_ln_k_i,sd=sd_ln_k_i),col="red")
text(m_ln_k_i-2*sd_ln_k_i,0.9,paste("m =",signif(m_ln_k_i,4),"\nsd =",signif(sd_ln_k_i,4)))

qqnorm(dat$ln_Vd_i,main="ln Vd Q-Q Normal")
qqline(dat$ln_Vd_i,col="red")
plot(ecdf(dat$ln_Vd_i))
x <- seq(-3,1,0.01)
m_ln_Vd_i <- mean(dat$ln_Vd_i)
sd_ln_Vd_i <- sd(dat$ln_Vd_i)

lines(x,pnorm(x,mean=m_ln_Vd_i,sd=sd_ln_Vd_i),col="red")
text(m_ln_Vd_i-2*sd_ln_Vd_i,0.9,paste("m =",signif(m_ln_Vd_i,4),"\nsd =",signif(sd_ln_Vd_i,4)))

```

## Calculate table values for individual-level
```{r make-individual-param-out, cache = TRUE}
hl_i <- log(2)/ exp(dat$ln_k_i) # individual half-life 
med_hl_i <- paste(signif (median (hl_i), 3)) # median of individual half-life
ci_med_hl_i <-   paste(signif (quantile(hl_i, prob=c(0.025,0.975)), 3),collapse="-") # 95ci med individual halflife
ci98_med_hl_i <-   paste(signif (quantile(hl_i, prob=c(0.01,0.99)), 3),collapse="-") # 98ci med individual halflife
gm_hl_i <- paste(signif (exp(mean(log(hl_i))), 3)) # gm (which should be really close)
gsd_hl_i <- paste(signif (exp(sd(log(hl_i))), 3)) # gsd individual

med_Vd_i <- paste(signif (median(exp(dat$ln_Vd_i)), 3)) # median individual Vd
ci_med_Vd_i <-paste(signif (quantile(exp(dat$ln_Vd_i), prob=c(0.025,0.975)), 3),collapse="-") # 95ci med individual Vd
ci98_med_Vd_i <-paste(signif (quantile(exp(dat$ln_Vd_i), prob=c(0.01,0.99)), 3),collapse="-") # 98ci med individual Vd
gm_vd_i <- paste(signif (exp(mean(dat$ln_Vd_i)), 3)) # gm (which should be really close)
gsd_vd_i<- paste(signif (exp(sd(dat$ln_Vd_i)), 3)) # gsd indiv
```


```{r half-life,fig.height=2.5,fig.width=4,dpi=600}
PFHxS_priors <- data.frame(
  halflife_GM= log(2)/rlnorm(50000,
                             meanlog=-2.03422,sdlog=0.4055))
M_k <- exp(as.numeric(dat$`M_ln_k(1)`))
PFHxS_halflife_GM <- log(2)/M_k

PFHxS_hlgm_pr_med <- signif(median(PFHxS_priors$halflife_GM,3))
PFHxS_hlgm_pr_med_95ci <-paste(signif(quantile(PFHxS_priors$halflife_GM,
                                            prob=c(0.025,0.975)),
                                   3),
                            collapse="-")

PFHxS_hl_median_gm <- signif(median(PFHxS_halflife_GM),3)
PFHxS_hl_median_gm_95ci <- paste(signif(quantile(PFHxS_halflife_GM,
                                            prob=c(0.025,0.975)),3),collapse="-")

p<-ggplot()+
  stat_density(aes(halflife_GM, color = "Prior"),data=PFHxS_priors,geom="line",size=2)+
  stat_density(aes(PFHxS_halflife_GM, stat(density),color="Posterior"),geom="line",size=1.5 )+
  xlim(0,15)+
  labs(title = bquote("G: PFHxS"~T[1/2]~"Population GM")  ,
       subtitle=paste("Posterior Median (95% CI): ",
                      PFHxS_hl_median_gm," (",
                      PFHxS_hl_median_gm_95ci,
                      ")",sep=""))+
  xlab(bquote("Population GM"~T[1/2]~"(yrs)")) +
  scale_color_manual(name=NULL,#
                    values=c(Prior="#009988", Posterior="#EE7733" )) + 
  theme_classic() +  
  theme(legend.title = element_blank(),legend.position=c(0.8,0.7),
      panel.background = element_rect(color="black",size=1),
      legend.background = element_rect(fill="transparent", color=NA))
print(p)
ggsave(here ("output-plots",paste0( sa, "PFHxS_hl_gm.pdf")),p,dpi=600)
 
```



```{r PFHxS-half-life-gsd, message=FALSE, warning=FALSE,fig.height=2.5,fig.width=4,dpi=600}
PFHxS_priors$halflife_GSD =  exp(sqrt(exp(rnorm(50000,m=log(0.2),sd=log(1.275))))) 
PFHxS_halflife_GSD <- exp(sqrt(dat$`V_ln_k(1)`))

PFHxS_hlgsd_pr_med <- signif(median(PFHxS_priors$halflife_GSD,3))
PFHxS_hlgsd_pr_med_95ci <-paste(signif(quantile(PFHxS_priors$halflife_GSD,
                                            prob=c(0.025,0.975)),
                                   3),
                            collapse="-")
PFHxS_hl_gsd_med <- signif(median(PFHxS_halflife_GSD),3)
PFHxS_hl_gsd_med_95ci <- paste(signif(quantile(PFHxS_halflife_GSD,
                                            prob=c(0.025,0.975)),3),collapse="-")
p<-ggplot()+
  stat_density(aes(halflife_GSD, color = "Prior"),data=PFHxS_priors,geom="line", size=2)+
  stat_density(aes(PFHxS_halflife_GSD,stat(density), color = "Posterior"),geom="line",size=1.5)+
  xlim(1,3)+
  labs(title = bquote("H: PFHxS"~T[1/2]~"Population GSD"),  
       subtitle=paste("Posterior Median (95% CI): ",
                      PFHxS_hl_gsd_med," (",
                      PFHxS_hl_gsd_med_95ci,
                      ")",sep=""))+
  xlab(bquote("Population GSD"~T[1/2]))+
  scale_color_manual(name=NULL,#
                    values=c(Prior="#009988", Posterior="#EE7733" )) + 
   theme_classic() +  
  theme(legend.title = element_blank(),legend.position=c(0.8,0.7),
      panel.background = element_rect(color="black",size=1),
      legend.background = element_rect(fill="transparent", color=NA))
print(p)
ggsave(here ("output-plots",paste0( sa, "PFHxS_hl_gsd.pdf")) ,p,dpi=600)

```


### Volume of distribution
For PFHxS, the data were not particularly informative, but slightly increased the estimate of the median to 0.308(0.223-0.548) slightly compared to the case where Cbgd was considered to be entirely from non-drinking water sources. They were not informative as to the population GSD, with the posterior distributions essentially unchanged from the priors.
```{r PFHxS-vd-gm, message=FALSE, warning=FALSE,fig.height=2.5,fig.width=4,dpi=600}
PFHxS_priors$Vd_GM <- rlnorm(50000,
                             meanlog=-1.38629,
                             sdlog=0.2624)
PFHxS_Vd_GM <- exp(dat$`M_ln_Vd(1)`)

 

PFHxS_vd_gm_pr_med <- signif(median(PFHxS_priors$Vd_GM,3))
PFHxS_vd_gm_pr_med_95ci <- paste(signif(quantile(PFHxS_priors$Vd_GM,
                                            prob=c(0.025,0.975)), 3), collapse="-")
PFHxS_vd_gm_med <- signif(median(PFHxS_Vd_GM),3)
PFHxS_vd_gm_med_95ci <- paste(signif(quantile(PFHxS_Vd_GM,
                                            prob=c(0.025,0.975)),3),collapse="-")

p<-ggplot()+
  stat_density(aes(Vd_GM, color = "Prior"),data=PFHxS_priors,geom="line",size=2)+
  stat_density(aes(PFHxS_Vd_GM,stat(density), color = "Posterior"),geom="line",size=1.5)+
  xlim(0,1)+labs(title = bquote("G: PFHxS"~V[d]~"Population GM"),
                 subtitle=paste("Posterior Median (95% CI): ",
                                PFHxS_vd_gm_med," (", 
                                PFHxS_vd_gm_med_95ci,")",sep=""))+
   xlab(bquote("Population GM"~V[d]~"(l/kg)"))+
  scale_color_manual(name=NULL,#
                    values=c(Prior="#009988", Posterior="#EE7733" )) +  
  theme_classic() +  
  theme(legend.title = element_blank(),legend.position=c(0.8,0.7),
      panel.background = element_rect(color="black",size=1),
      legend.background = element_rect(fill="transparent", color=NA))
print(p)
ggsave(here ("output-plots",paste0( sa, "PFHxS_vd_gm.pdf")) ,p,dpi=600)

```


```{r PFHxS-vd-sd, message=FALSE, warning=FALSE,fig.height=2.5,fig.width=4,dpi=600}
PFHxS_priors$Vd_GSD = exp(abs(rnorm(50000,sd=0.17)))
PFHxS_Vd_GSD <- exp(dat$`SD_ln_Vd(1)`)

PFHxS_vd_gsd_pr_med <- signif(median(PFHxS_priors$Vd_GSD,3))
PFHxS_vd_gsd_pr_med_95ci <- paste(signif(quantile(PFHxS_priors$Vd_GSD,
                                            prob=c(0.025,0.975)), 3), collapse="-")

PFHxS_vd_gsd_med <- signif(median(PFHxS_Vd_GSD),3)
PFHxS_vd_gsd_med_95ci <- paste(signif(quantile(PFHxS_Vd_GSD,
                                            prob=c(0.025,0.975)),3),collapse="-")

p<-ggplot()+
  stat_density(aes(Vd_GSD, color = "Prior"),data=PFHxS_priors,geom="line",size=2)+
  stat_density(aes(PFHxS_Vd_GSD,stat(density), color = "Posterior"),geom="line",size=1.5)+
  xlim(1,3)+
  labs(title = bquote("H: PFHxS"~V[d]~"Population GSD "),
       subtitle=paste("Posterior Median (95% CI): ",
                      PFHxS_vd_gsd_med," (",
                      PFHxS_vd_gsd_med_95ci,
                      ")",sep=""))+
  xlab(bquote("Population GSD"~V[d]))+
  scale_color_manual(name=NULL, 
                     values=c(Prior="#009988", Posterior="#EE7733" )) + 
  theme_classic() +  
  theme(legend.title = element_blank(),legend.position=c(0.8,0.7),
      panel.background = element_rect(color="black",size=1),
      legend.background = element_rect(fill="transparent", color=NA))
print(p)
ggsave(here ("output-plots",paste0( sa,"PFHxS_vd_gsd.pdf")) ,p,dpi=600)

```
### Clearance (just pop GM)

Cl is k * Vd

```{r PFHxS-cl-gm, message=FALSE, warning=FALSE,fig.height=2.5,fig.width=4,dpi=600}
PFHxS_priors$CL_GM <- PFHxS_priors$Vd_GM * (log(2)/PFHxS_priors$halflife_GM)
PFHxS_CL_GM <- exp(dat$`M_ln_Vd(1)` + dat$`M_ln_k(1)`)

PFHxS_cl_gm_pr_med <- signif(median(PFHxS_priors$CL_GM,3))
PFHxS_cl_gm_pr_med_95ci <- paste(signif(quantile(PFHxS_priors$CL_GM,
                                            prob=c(0.025,0.975)), 3), collapse="-")
PFHxS_cl_gm_med <- signif(median(PFHxS_CL_GM),3)
PFHxS_cl_gm_med_95ci <- paste(signif(quantile(PFHxS_CL_GM,
                                            prob=c(0.025,0.975)),3),collapse="-")

p<-ggplot()+
  stat_density(aes(CL_GM, color = "Prior"),data=PFHxS_priors,geom="line",size=2)+
  stat_density(aes(PFHxS_CL_GM,stat(density), color = "Posterior"),geom="line",size=1.5)+
  xlim(0,0.25)+labs(title = "D: PFHxS Clearance Pop. GM ",subtitle=paste("Posterior Median (95% CI): ",
                                                                    PFHxS_cl_gm_med," (",
                                                                    PFHxS_cl_gm_med_95ci,
                                                                    ")",sep=""))+
  xlab("Pop. GM CL (l/(kg-yr))")+
  scale_color_manual(name=NULL,#
                    values=c(Prior="#009988", Posterior="#EE7733" )) +  
  theme_classic() +  
  theme(legend.title = element_blank(),legend.position=c(0.8,0.7),
      panel.background = element_rect(color="black",size=1),
      legend.background = element_rect(fill="transparent", color=NA))
print(p)
ggsave(here ("output-plots",paste0( sa, "PFHxS_CL_gm.pdf")), p,dpi=600)

```


## Table significant digit values

```{r table-vars }
PFHxS_hlgm_pr_med <- paste(signif(PFHxS_hlgm_pr_med, 3))
PFHxS_hl_median_gm<- paste(signif(PFHxS_hl_median_gm, 3))
PFHxS_hlgsd_pr_med<- paste(signif(PFHxS_hlgsd_pr_med, 3))
PFHxS_hl_gsd_med<- paste(signif(PFHxS_hl_gsd_med, 3))
PFHxS_vd_gm_pr_med<- paste(signif(PFHxS_vd_gm_pr_med, 3))
PFHxS_vd_gm_med<- paste(signif(PFHxS_vd_gm_med, 3))
PFHxS_vd_gsd_pr_med<- paste(signif(PFHxS_vd_gsd_pr_med, 3))
PFHxS_vd_gsd_med<- paste(signif(PFHxS_vd_gsd_med, 3))
PFHxS_cl_gm_pr_med<- paste(signif(PFHxS_cl_gm_pr_med, 3))
PFHxS_cl_gm_med<- paste(signif(PFHxS_cl_gm_med, 3))
```

### Population median estimates [95% CI] 

| Parameter                      | Prior GM      | Posterior GM | Prior  GSD    | Posterior GSD | 
| -------------------------------|:-------------:|:------------:|:-------------:|:-------------:| 
| Half-life (years)  | `r paste(PFHxS_hlgm_pr_med) ` |   `r paste(PFHxS_hl_median_gm) `    | `r  paste(PFHxS_hlgsd_pr_med) `           | `r paste(PFHxS_hl_gsd_med)`  | 
| HL  [95% CI]  |`r paste0("[",PFHxS_hlgm_pr_med_95ci,"]")` | `r paste0( "[",PFHxS_hl_median_gm_95ci,"]")`| `r paste0("[",PFHxS_hlgsd_pr_med_95ci,"]")`| `r paste0( "[",PFHxS_hl_gsd_med_95ci, "]")`|
| Volume of distribution    | `r paste(PFHxS_vd_gm_pr_med) ` |    `r paste(  PFHxS_vd_gm_med) `|   `r  paste(PFHxS_vd_gsd_pr_med)`  |`r  paste(PFHxS_vd_gsd_med)` |  
| $V_D$ [95% CI]    |`r paste0( "[",PFHxS_vd_gm_pr_med_95ci,"]")`| `r paste0( "[",PFHxS_vd_gm_med_95ci,"]")`| `r paste0("[",PFHxS_vd_gsd_pr_med_95ci, "]")`| `r paste0(  "[",PFHxS_vd_gsd_med_95ci, "]")`| 
| Clearance    | `r paste(PFHxS_cl_gm_pr_med) ` |    `r paste(  PFHxS_cl_gm_med) `|   `r  paste()`  |`r  paste()` |  
| $CL$ [95% CI]    |`r paste0( "[",PFHxS_cl_gm_pr_med_95ci,"]")`| `r paste0( "[",PFHxS_cl_gm_med_95ci,"]")`| `r paste0("[", "]")`| `r paste0(  "[", "]")`| 
 


### Individual Posterior estimates 

| Parameter                      |  median GM  [95% CI] [[98% CI]] | GM calculator input  |  GSD individual |
| -------------------------------|:--------------------:|:--------------------:|:---------------------:| 
| Half-life (years)              | `r  paste(med_hl_i, "[",ci_med_hl_i,"]", "[[",ci98_med_hl_i,"]]") ` | `r  paste(gm_hl_i) ` | `r  paste(gsd_hl_i) `|
| Volume of distribution $V_D$   | `r  paste(med_Vd_i, "[",ci_med_Vd_i,"]", "[[",ci98_med_Vd_i,"]]") ` | `r  paste(gm_vd_i) ` | `r  paste(gsd_vd_i) `| 



### Session information
```{r echo=FALSE}
devtools::session_info()
```